Royal Air Force Typhoon FGR4s have joined forces with France's air force in a joint strike on an subterranean weapons facility in Syrian territory operated by the Daesh militant organization, according to the UK's MoD.
The location, pinpointed through surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized Paveway IV guided bombs to strike a number of entry passages down to the site... initial indications are that the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the attack conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as ISIS - imposed jihadist rule over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This operation underscores British leadership, and determination to operate in unison with allied nations, to stamp out any revival of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey stated.
British military aircraft have conducted surveillance missions over Syrian airspace to "deter any efforts to regroup" of Islamic State subsequent to its defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of the UK armed forces involved in this mission for their expertise and their bravery," the Defence Secretary added. "They were part of a great many UK service members deployed over the holidays. This mission, to take out dangerous terrorists who endanger our safety, shows how UK forces are always on standby, throughout the year, ensuring Britain's security at home and influential overseas."
During December, the American forces carried out what it termed a "major assault" against Islamic State objectives in Syria, after an assault resulted in the deaths of two US troops and a civilian interpreter in the Palmyra area.
The United Nations estimates IS still has between 5,000 and 7,000 fighters in Syria and Iraq.