The artist has donated the full amount of his £25k honor prize money to the trust for venues, which functions to save the United Kingdom's independent concert spaces.
The star was awarded the cheque on 16 October as his latest record People Watching was named the best record of the last 12 months.
Fender has chosen to hand the money over to the Music Venues Trust, in recognition of the essential function local spots played in his initial steps.
"I would not have achieved my current career if it wasn't for all the shows I played around the region, and further afield, when I was beginning," stated Sam Fender. "These spaces are renowned, but they are struggling."
Since the start of 2023, at least 150 of these venues have shut down – roughly one-sixth of the entire UK sector.
Over the past year, well-known musicians like Pulp, the group Coldplay, the singer Katy Perry and Sheeran have all supported the Music Venues Trust in its efforts to help venues survive, by applying a small levy to their admission fees, which benefits independent venues.
Fender also participated, generating in excess of £100,000 on his recent tour to assist 38 local spots across Britain.
The money helped venues that were confronting imminent closure due to issues caused by flooding, blazes and family tragedies, as well as permit problems, conflicts and noise complaints.
Other venues were granted financial assistance in upgrading facilities and technical equipment that helped performers and audiences.
"The notion that money from shows in major spaces supports the smaller venues, where it kicks off for artists like me, is just logical," the star has said.
Fender is far from the only musician to give his Mercury Prize funds to good deeds.
Back when Pulp earned the trophy in the mid-90s for their album the album, frontman the singer stated that the band would give their cash to the charity the charity.
In 2002, rapper and singer Ms Dynamite divided her prize across a few charities, such as the NSPCC and a Sickle Cell organization.
"And I contributed a grand to the center, to their classes, because I practiced gymnastics when I was a child and they lacked new equipment," Ms Dynamite shared with the media.
Previously, Ezra Collective donated their winnings to the local youth club that developed their group, in addition to other independent music bodies.
Additionally the 1994 recipients they gave their prize to a MS organization after a friend was diagnosed the illness.
"Receiving the award was sufficient," said vocalist Small. "The prize was the cherry on top but we could do without the bonus, because we had the honor. So our success impacted another person's life."
Last week, the MVT announced it had protected several small stages in south-east England, by bringing them into community ownership.
One venue in that area and the second in Bristol were bought under the community ownership program, which is funded by a national body and enthusiasts who purchase "ownership units" in the properties.